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lüll The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis Lee YH; Rho YH; Choi SJ; Ji JD; Song GG; Nath SK; Harley JBRheumatology (Oxford) 2007[Jan]; 46 (1): 49-56OBJECTIVE: To assess whether combined evidence shows the association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) C1858T polymorphism and autoimmune diseases, and to summarize the effect size of the polymorphism associated with susceptibility of autoimmune diseases. METHODS: We surveyed studies on the PTPN22 C1858T polymorphism and autoimmune diseases using comprehensive Medline search and review of the references. Meta-analysis was performed for genotypes T/T (recessive effect), T/T + C/T (dominant effect) and T-allele in random effects models. RESULTS: Twenty-nine studies with 43 comparisons including 13 rheumatoid arthritis (RA), six systemic lupus erythematosus (SLE), six type-1 DM (T1D), three Grave's disease (GD), four inflammatory bowel diseases (IBD), three juvenile idiopathic arthritis (JIA), two psoriasis, two multiple sclerosis, two Addison's disease and two Celiac disease were available for the meta-analysis. The overall odds ratios (ORS) for T-allele, T/T and T/T + C/T genotypes were significantly increased in RA, SLE, GD and T1D (OR for T-allele = 1.58, 1.49, 1.85, 1.61, respectively, P < 0.00001). This meta-analysis showed the association between the T-allele and the T/T genotype and JIA (OR = 1.34, P = 0.03; OR = 1.97, P = 0.02) but did not reveal the association between the PTPN22 C1858T polymorphism and IBD, psoriasis, multiple sclerosis, Addison's disease and Celiac disease. CONCLUSION: This meta-analysis demonstrates that the PTPN22 1858T allele confers susceptibility to RA, SLE, GD, T1D and JIA, supporting evidence of association of the PTPN22 gene with subgroup of autoimmune diseases.|*Polymorphism, Single Nucleotide[MESH]|Autoimmune Diseases/*genetics[MESH]|Genetic Predisposition to Disease[MESH]|Genotype[MESH]|Humans[MESH]|Protein Tyrosine Phosphatase, Non-Receptor Type 1[MESH]|Protein Tyrosine Phosphatase, Non-Receptor Type 22[MESH]|Protein Tyrosine Phosphatases/*genetics[MESH]|Rheumatic Diseases/genetics[MESH] |