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lüll Staying in shape with formins Faix J; Grosse RDev Cell 2006[Jun]; 10 (6): 693-706Formins constitute a diverse protein family present in all eukaryotes examined. They are defined by the presence of a formin homology 2 (FH2) domain, which possesses intrinsic and conserved functions regulating cytoskeletal dynamics. Over the past few years, formins have become recognized as potent nucleators of linear actin filaments that control a large variety of cellular and morphogenetic functions. Here, we review the molecular principles of formin-induced cytoskeletal rearrangements and their consequences for a growing number of biological processes.|Actin Cytoskeleton/chemistry/*metabolism[MESH]|Animals[MESH]|Contractile Proteins/metabolism[MESH]|Humans[MESH]|Microfilament Proteins/chemistry/*physiology[MESH]|Models, Biological[MESH]|Protein Binding[MESH]|Protein Structure, Tertiary[MESH] |