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Paradigm lost: milton connects kinesin heavy chain to miro on mitochondria Rice SE; Gelfand VIJ Cell Biol 2006[May]; 173 (4): 459-61The kinesin motor typically binds to cargo through its light chains. In this issue Glater et al. demonstrate a new type of linkage through the adapter protein, milton, and the mitochondrial membrane GTPase, miro. This is an important result because it represents a new mechanism of cargo binding and because miro's ability to bind GTP and calcium suggests that it is involved in the regulation of mitochondrial transport.|Animals[MESH]|Drosophila Proteins/*metabolism[MESH]|Humans[MESH]|Kinesins/*metabolism[MESH]|Mitochondria/*metabolism[MESH]|Mitochondrial Membrane Transport Proteins/*metabolism[MESH]|Nerve Tissue Proteins/*metabolism[MESH]|Protein Transport/physiology[MESH]|rho GTP-Binding Proteins/*metabolism[MESH] |
