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The growth factor independence-1 transcription factor: new functions and new insights Kazanjian A; Gross EA; Grimes HLCrit Rev Oncol Hematol 2006[Aug]; 59 (2): 85-97The growth factor independence-1 (Gfi1) transcription factor is required for proper development of neuroendocrine cells, sensory neurons, and blood. Patients with mutations in Gfi1 exhibit severe congenital neutropenia (SCN) or non-immune chronic idiopathic neutropenia of adults. Gfi1 was initially described as an oncoprotein that mediates tumor progression in a mouse model of leukemia; however, recent data suggest that Gfi1 may act as either an oncogene or an anti-proliferative tumor suppressor gene depending on the cell type. Here we review the latest literature on Gfi1, and emphasize its role in the hematopoietic, sensory and neuroendocrine systems.|Animals[MESH]|DNA-Binding Proteins/genetics/*metabolism[MESH]|Hematopoiesis/genetics[MESH]|Humans[MESH]|Mice[MESH]|Neurons, Afferent/metabolism[MESH]|Neurosecretory Systems/metabolism[MESH]|Neutropenia/genetics/metabolism[MESH]|Oncogene Proteins/genetics/*metabolism[MESH]|Organ Specificity[MESH]|Transcription Factors/genetics/*metabolism[MESH]|Tumor Suppressor Proteins/genetics/*metabolism[MESH] |
