Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme Charalambous C; Chen TC; Hofman FMNeurosurg Focus 2006[Apr]; 20 (4): E22Glioblastomas multiforme (GBMs) are highly vascular brain tumors characterized by abnormal vessel structures in vivo. This finding supports the theory that glioma-associated endothelial cells (ECs) have intrinsically different properties from ECs in normal human brain. Therefore, identification of the functional and phenotypic characteristics of tumor-associated ECs is essential for designing a rational antiangiogenic therapy. The GBM-associated ECs have a large, flat, and veil-like appearance, in contrast to normal ones, which are small and plump. Although the tumor ECs have the typical markers, they proliferate more slowly than these cell types in normal brain. The GBM-associated ECs are resistant to cytotoxic drugs, and they undergo less apoptosis than control cells. Also, GBM-associated ECs migrate faster than controls and constitutively produce high levels of growth factors such as endothelin-1, interleukin-8, and vascular endothelial growth factor. An understanding of these unique characteristics of glioma-associated ECs is important for the development of novel antiangiogenic agents that specifically target tumor-associated ECs in gliomas.|Angiogenesis Inhibitors/pharmacology[MESH]|Biomarkers, Tumor/metabolism[MESH]|Blood Vessels/*metabolism/pathology/physiopathology[MESH]|Brain Neoplasms/*blood supply/drug therapy/physiopathology[MESH]|Cell Proliferation[MESH]|Drug Resistance, Neoplasm/physiology[MESH]|Endothelial Cells/drug effects/*metabolism/pathology[MESH]|Endothelial Growth Factors/*biosynthesis/metabolism[MESH]|Glioblastoma/*blood supply/drug therapy/physiopathology[MESH]|Humans[MESH]|Neovascularization, Pathologic/drug therapy/*metabolism/physiopathology[MESH] |