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lüll Mantle cell lymphoma: an update on management Zelenetz ADAnn Oncol 2006[May]; 17 Suppl 4 (ä): iv12-4Although response rates are increased, the addition of rituximab to induction chemotherapy has not yet been proven to extend the progression-free and overall survival benefits of chemotherapy alone. In first remission, high-dose therapy plus stem cell rescue improves time to treatment failure and progression-free survival when compared with maintenance interferon alpha. However, relapse rate does not reach a plateau. Radioimmunotherapy has substantial single-agent activity and when combined with chemotherapy may provide a platform onto which rituximab or autologous stem cell transplantation can be added. Targeted therapies are also showing promise and may have a role in maintenance and/or initial therapy.|Antineoplastic Combined Chemotherapy Protocols/therapeutic use[MESH]|Combined Modality Therapy[MESH]|Humans[MESH]|Lymphoma, Mantle-Cell/*therapy[MESH]|Radioimmunotherapy[MESH]|Stem Cell Transplantation[MESH] |