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lüll Rimonabant: a cannabinoid receptor type 1 blocker for management of multiple cardiometabolic risk factors Gelfand EV; Cannon CPJ Am Coll Cardiol 2006[May]; 47 (10): 1919-26Rimonabant is a first selective blocker of the cannabinoid receptor type 1 (CB1) being developed for the treatment of multiple cardiometabolic risk factors, including abdominal obesity and smoking. In four large trials, after one year of treatment, rimonabant 20 mg led to greater weight loss and reduction in waist circumference compared with placebo. Therapy with rimonabant is also associated with favorable changes in serum lipid levels and an improvement in glycemic control in prediabetes patients and in type 2 diabetic patients. At the same dose, rimonabant significantly increased cigarette smoking quit rates as compared with placebo. Rimonabant seems to be well tolerated, with a primary side effect of mild nausea. As an agent with a novel mechanism of action, rimonabant has a potential to be a useful adjunct to lifestyle and behavior modification in treatment of multiple cardiometabolic risk factors, including abdominal obesity and smoking.|Animals[MESH]|Atherosclerosis/drug therapy[MESH]|Blood Glucose/drug effects[MESH]|Cannabinoid Receptor Modulators/*pharmacology/therapeutic use[MESH]|Cardiovascular Diseases/*drug therapy[MESH]|Cardiovascular System/drug effects[MESH]|Clinical Trials as Topic[MESH]|Diabetes Mellitus, Type 2/drug therapy[MESH]|Humans[MESH]|Lipid Metabolism/drug effects[MESH]|Marijuana Abuse/physiopathology[MESH]|Metabolic Syndrome/*drug therapy[MESH]|Obesity/*drug therapy[MESH]|Piperidines/*pharmacology/therapeutic use[MESH]|Pyrazoles/*pharmacology/therapeutic use[MESH]|Receptor, Cannabinoid, CB1/antagonists & inhibitors[MESH]|Rimonabant[MESH]|Smoking Cessation[MESH] |