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The T-box transcription factor T-bet in immunity and autoimmunity Peng SLCell Mol Immunol 2006[Apr]; 3 (2): 87-95The T-box transcription factor T-bet (Tbx21) has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in T and B lymphocytes, as well as dendritic cells and natural killer cells. Several autoimmune diseases, especially those classically considered related to T helper 1 (Th1) immunity, appear to require T-bet, at least as judged in mouse models. This review summarizes a current understanding of T-bet's role in immunity, as well as its importance in autoimmunity, with implications for therapeutic intervention.|*Immunity[MESH]|Animals[MESH]|Autoimmune Diseases/drug therapy/*immunology[MESH]|B-Lymphocytes/immunology[MESH]|Drug Delivery Systems[MESH]|Humans[MESH]|T-Box Domain Proteins[MESH]|T-Lymphocytes/immunology[MESH]|T-bet Transcription Factor[MESH]|Transcription Factors/*immunology[MESH] |
