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  • Epigenetics, evolution, endocrine disruption, health, and disease
  • Crews D; McLachlan JA
  • Endocrinology 2006[Jun]; 147 (6 Suppl): S4-10
  • Endocrine-disrupting chemicals (EDCs) in the environment have been linked to human health and disease. This is particularly evident in compounds that mimic the effects of estrogens. Exposure to EDCs early in life can increase risk levels of compromised physical and mental health. Epigenetic mechanisms have been implicated in this process. Transgenerational consequences of EDC exposure is also discussed in both a proximate (mechanism) and ultimate (evolution) context as well as recent work suggesting how such transmission might become incorporated into the genome and subject to selection. We suggest a perspective for exploring and ultimately coming to understand diseases that may have environmental or endocrine origins.
  • |*Biological Evolution[MESH]
  • |*Endocrine Disruptors/toxicity[MESH]
  • |*Epigenesis, Genetic[MESH]
  • |*Health Status[MESH]
  • |Adult[MESH]
  • |Animals[MESH]
  • |Disease/etiology[MESH]
  • |Environmental Exposure[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Mental Disorders/etiology[MESH]
  • |Pregnancy[MESH]
  • |Prenatal Exposure Delayed Effects[MESH]





  • *{{pmid16690812}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=16690812 Epigenetics, evolution, endocrine disruption, health, and disease ]</b> Endocrinology 2006; 147(6 Suppl) ; S4-10 Crews D; McLachlan JA

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    Endocrinology

    S4 6 Suppl.147 2006