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Human polynucleotide phosphorylase (hPNPase old-35): an RNA degradation enzyme with pleiotrophic biological effects Sarkar D; Fisher PBCell Cycle 2006[May]; 5 (10): 1080-4Identification of small inhibitory RNAs and microRNA established that regulation of RNA metabolism plays an essential role in controlling intracellular biochemical processes. Interferons induce a number of RNA degradation enzymes involved in innate immunity by degrading viral RNAs. We cloned human polynucleotide phosphorylase (hPNPase(old-35)), a type I interferon-inducible 3'-5' exoribonuclease, as a transcript induced during terminal differentiation and senescence, two physiological processes marked by irreversible growth arrest. Our studies in the last four years show that hPNPase(old-35) plays an essential role in mediating IFN-mediated growth inhibition and its upregulation might mediate chronic inflammatory pathological processes during aging. The present review recaps these findings and provides a framework for the future understanding of the versatile functions of this interesting molecule.|*Gene Expression Regulation[MESH]|Aging/*metabolism[MESH]|Animals[MESH]|Cell Line, Tumor[MESH]|Cell Proliferation/drug effects[MESH]|Cellular Senescence/drug effects[MESH]|Cloning, Molecular[MESH]|Exoribonucleases/biosynthesis/genetics/*metabolism[MESH]|Humans[MESH]|Inflammation/enzymology[MESH]|Interferon-beta/pharmacology[MESH]|Mitochondria/enzymology[MESH]|Promoter Regions, Genetic[MESH]|Protein Conformation[MESH]|Proto-Oncogene Proteins c-myc/genetics/metabolism[MESH]|RNA Stability[MESH]|RNA, Messenger/metabolism[MESH]|RNA, Mitochondrial[MESH]|RNA/metabolism[MESH] |
