Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A Ruderman NB; Saha AKObesity (Silver Spring) 2006[Feb]; 14 Suppl 1 (ä): 25S-33SThe metabolic syndrome can be defined as a state of metabolic dysregulation characterized by insulin resistance, central obesity, and a predisposition to type 2 diabetes, dyslipidemia, premature atherosclerosis, and other diseases. An increasing body of evidence has linked the metabolic syndrome to abnormalities in lipid metabolism that ultimately lead to cellular dysfunction. We review here the hypothesis that, in many instances, the cause of these lipid abnormalities could be a dysregulation of the adenosine monophosphate-activated protein kinase (AMPK)/malonyl coenzyme A (CoA) fuel-sensing and signaling mechanism. Such dysregulation could be reflected by isolated increases in malonyl CoA or by concurrent changes in malonyl CoA and AMPK, both of which would alter intracellular fatty acid partitioning. The possibility is also raised that pharmacological agents and other factors that activate AMPK and/or decrease malonyl CoA could be therapeutic targets.|*Insulin Resistance[MESH]|AMP-Activated Protein Kinases[MESH]|Animals[MESH]|Energy Metabolism/*physiology[MESH]|Humans[MESH]|Lipid Metabolism/*physiology[MESH]|Malonyl Coenzyme A/*metabolism[MESH]|Metabolic Syndrome/*enzymology[MESH]|Multienzyme Complexes/*metabolism[MESH]|Protein Serine-Threonine Kinases/*metabolism[MESH]|Signal Transduction[MESH] |