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Non-viral vectors for cancer therapy Kaneda Y; Tabata YCancer Sci 2006[May]; 97 (5): 348-54Cancers are diverse and often resistant to therapeutic strategies. Gene therapy has yet to meet the promise of a breakthrough in cancer therapy. There are several barriers to overcome in cancer gene therapy. One of the biggest challenges is the design of appropriate vectors. Numerous viral and non-viral methods for gene transfer have been developed for human gene therapy, but both viral and non-viral vectors have limitations and advantages. In this review article, recent improvements in the development of non-viral vectors for delivering gene therapy for the treatment of cancer will be discussed.|*Gene Transfer Techniques[MESH]|*Genetic Vectors[MESH]|Animals[MESH]|Cisplatin/metabolism/pharmacology[MESH]|Electroporation/methods[MESH]|Genetic Therapy/*methods[MESH]|Humans[MESH]|Liposomes/metabolism/pharmacology/therapeutic use[MESH]|Mice[MESH]|Mice, Nude[MESH]|Models, Biological[MESH]|Neoplasms/metabolism/*therapy[MESH]|Polymers/metabolism/pharmacology/therapeutic use[MESH]|Sendai virus/metabolism[MESH]|Ultrasonics[MESH] |
