Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Thematic review series: lipid posttranslational modifications Lysosomal metabolism of lipid-modified proteins Lu JY; Hofmann SLJ Lipid Res 2006[Jul]; 47 (7): 1352-7Much is now understood concerning the synthesis of prenylated and palmitoylated proteins, but what is known of their metabolic fate? This review details metabolic pathways for the lysosomal degradation of S-fatty acylated and prenylated proteins. Central to these pathways are two lysosomal enzymes, palmitoyl-protein thioesterase (PPT1) and prenylcysteine lyase (PCL). PPT1 is a soluble lipase that cleaves fatty acids from cysteine residues in proteins during lysosomal protein degradation. Notably, deficiency in the enzyme causes a neurodegenerative lysosomal storage disorder, infantile neuronal ceroid lipofuscinosis. PCL is a membrane-associated flavin-containing lysosomal monooxygenase that metabolizes prenylcysteine to prenyl aldehyde through a completely novel mechanism. The eventual metabolic fates of other lipidated proteins (such as glycosylphosphatidylinositol-anchored and N-myristoylated proteins) are poorly understood, suggesting directions for future research.|*Lipid Metabolism[MESH]|Animals[MESH]|Carbon-Sulfur Lyases/metabolism[MESH]|Glycosylphosphatidylinositols/chemistry/metabolism[MESH]|Humans[MESH]|Lysosomes/*metabolism[MESH]|Models, Molecular[MESH]|Mutation[MESH]|Myristic Acids/chemistry/metabolism[MESH]|Protein Prenylation[MESH]|Protein Processing, Post-Translational[MESH]|Proteins/chemistry/genetics/*metabolism[MESH]|Thiolester Hydrolases/chemistry/genetics/metabolism[MESH] |