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lüll Natural history of cerebral vein thrombosis: a systematic review Dentali F; Gianni M; Crowther MA; Ageno WBlood 2006[Aug]; 108 (4): 1129-34Cerebral vein thrombosis (CVT) has been considered, until a few years ago, an uncommon disease with significant long-term morbidity and high mortality rate. New noninvasive diagnostic techniques have increased the frequency with which this disease is diagnosed; despite this, there continues to be little data on its natural history. The objectives of this study were to evaluate the mortality rate, the rate of disability at long-term follow-up, and the incidence of recurrence after a first episode of CVT; to determine clinical and radiologic predictors of death and dependence; and to identify possible risk factors for recurrence. ( DATA SOURCE: MEDLINE and EMBASE databases, reference lists of selected articles and authors' libraries.) Nineteen studies were identified. Mortality rate during peri-hospitalization period is 5.6% (range, 0%-15.2%) and 9.4% (range, 0%-39%) at the end of follow-up period. Eighty-eight percent of surviving patients recover completely or have only a mild functional or cognitive deficit. Two thirds of patients with CVT recanalized within the first few months after presentation, and 2.8% (range, 0%-11.7%) had objectively confirmed recurrence. We conclude that patients with CVT have a low risk of death and that most patients have a good long-term prognosis.|*Recovery of Function[MESH]|Diagnosis, Differential[MESH]|Disease-Free Survival[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Hospital Mortality[MESH]|Humans[MESH]|Incidence[MESH]|Intracranial Thrombosis/diagnosis/*mortality/*physiopathology[MESH]|MEDLINE[MESH]|Male[MESH]|Prognosis[MESH]|Recurrence[MESH]|Risk Factors[MESH] |