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lüll Multiple functions of Notch signaling in self-renewing organs and cancer Wilson A; Radtke FFEBS Lett 2006[May]; 580 (12): 2860-8In recent years a substantial body of evidence has accumulated to support the notion that signaling pathways known to be important during embryonic development play important roles in regulating self-renewing tissues. Moreover, the same pathways are often deregulated during tumorigenesis due to mutations of key elements of these pathways. The Notch signaling cascade meets all of the above-mentioned criteria. We discuss here the pleiotropic roles of the Notch signaling pathway in three different self-renewing organs (intestine, hematopoietic system and skin) and how its deregulation is involved in tumorigenesis.|*Signal Transduction[MESH]|Animals[MESH]|Cell Differentiation[MESH]|Hematopoiesis[MESH]|Humans[MESH]|Intestines/cytology[MESH]|Neoplasms/*metabolism/pathology[MESH]|Receptors, Notch/*metabolism[MESH] |