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Role of resistin in inflammation and inflammation-related diseases Pang SS; Le YYCell Mol Immunol 2006[Feb]; 3 (1): 29-34Resistin is a newly identified adipocyte secreted hormone belonging to a cysteine-rich protein family. It is expressed in white adipose tissues in rodents and has also been found in several other tissues in human. Insulin, glucose, many cytokines and anti-diabetic thiazolidinediones are regulators of resistin gene expression. Resistin was firstly proposed to be involved in insulin resistance and type 2 diabetes. Recently, it was found to be relevant to inflammation and inflammation-related diseases like atherosclerosis and arthritis.|*Gene Expression Regulation/drug effects[MESH]|Adipose Tissue/*metabolism[MESH]|Animals[MESH]|Arthritis/drug therapy/*metabolism[MESH]|Atherosclerosis/drug therapy/*metabolism[MESH]|Diabetes Mellitus, Type 1/drug therapy/metabolism[MESH]|Diabetes Mellitus, Type 2/drug therapy/metabolism[MESH]|Humans[MESH]|Hypoglycemic Agents/therapeutic use[MESH]|Inflammation/drug therapy/*metabolism[MESH]|Insulin Resistance[MESH]|Mice[MESH]|Rats[MESH]|Resistin/*metabolism[MESH]|Thiazolidinediones/therapeutic use[MESH] |
