Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Endocrine functions of bile acids Houten SM; Watanabe M; Auwerx JEMBO J 2006[Apr]; 25 (7): 1419-25Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in the liver from cholesterol, are the chief components of bile. Besides their well-established roles in dietary lipid absorption and cholesterol homeostasis, it has recently emerged that BAs are also signaling molecules, with systemic endocrine functions. BAs activate mitogen-activated protein kinase pathways, are ligands for the G-protein-coupled receptor TGR5, and activate nuclear hormone receptors such as farnesoid X receptor alpha. Through activation of these diverse signaling pathways, BAs can regulate their own enterohepatic circulation, but also triglyceride, cholesterol, energy, and glucose homeostasis. Thus, BA-controlled signaling pathways are promising novel drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.|*Signal Transduction[MESH]|Animals[MESH]|Bile Acids and Salts/*physiology[MESH]|Cholesterol/metabolism[MESH]|DNA-Binding Proteins/metabolism[MESH]|Endocrine System/*physiology[MESH]|Energy Metabolism[MESH]|Enzyme Activation[MESH]|Glucose/metabolism[MESH]|Homeostasis[MESH]|Humans[MESH]|Ligands[MESH]|Lipid Metabolism[MESH]|Liver/metabolism[MESH]|MAP Kinase Signaling System/physiology[MESH]|Receptors, Cytoplasmic and Nuclear[MESH]|Receptors, G-Protein-Coupled/metabolism[MESH]|Transcription Factors/metabolism[MESH] |