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lüll Novel approaches to new therapies for hepatitis B virus infection Loomba R; Liang TJAntivir Ther 2006[]; 11 (1): 1-15Hepatitis B is one of the most prevalent viral diseases in the world. It leads to chronic liver disease in 10% of infected individuals, putting them at an increased risk for liver-related morbidity and mortality from complications of cirrhosis and hepatocellular carcinoma. Despite the success of universal hepatitis B vaccination in many countries, this disease remains a major public health problem, resulting in more than 500,000 deaths per year. Although the current therapy for chronic hepatitis B (CHB) is effective, it is not optimal; novel approaches to the management of CHB are needed. An improved understanding of virus-host interactions, advances in gene therapy, the development of molecular therapies targeted at different stages of the hepatitis B virus life cycle, and new insights into various approaches of immune modulation will lead to the development of better therapeutic agents for the management of CHB. These advances herald a new era of combination therapy. In this review, we will discuss emerging therapies and potential mechanisms, and highlight the promises and pitfalls of these new treatment strategies.|*Genetic Therapy[MESH]|*Hepatitis B virus/drug effects/genetics[MESH]|Antiviral Agents/*therapeutic use[MESH]|Hepatitis B, Chronic/drug therapy/immunology[MESH]|Hepatitis B/*drug therapy/*immunology[MESH]|Humans[MESH] |