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lüll Ca(2+)-storage organelles Krause KHFEBS Lett 1991[Jul]; 285 (2): 225-9Intracellular Ca(2+)-storage organelles are found in virtually all eukaryotic cells. They play an important role in the regulation of the cytosolic free Ca2+ concentration and, thereby, in the regulation of cellular activity. Ca(2+)-storage organelles consist, in the simplest model of a Ca2+ pump, of a Ca(2+)-storage protein and a Ca(2+)-release channel. The primary structure of these functionally important proteins of Ca(2+)-storage organelles is similar in different cell types and conserved through evolution. In contrast, their spatial arrangement and, thus, the architecture of Ca(2+)-storage organelles may vary dramatically from one cell type to another.|Biological Transport, Active[MESH]|Calcium Channels/metabolism[MESH]|Calcium-Binding Proteins/*metabolism[MESH]|Calcium/*metabolism[MESH]|Calreticulin[MESH]|Calsequestrin/metabolism[MESH]|Endoplasmic Reticulum[MESH]|Models, Biological[MESH]|Organelles/*metabolism[MESH]|Sarcoplasmic Reticulum[MESH] |