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lüll Invasion of red blood cells by malaria parasites Cowman AF; Crabb BSCell 2006[Feb]; 124 (4): 755-66The malaria parasite is the most important member of the Apicomplexa, a large and highly successful phylum of intracellular parasites. Invasion of host cells allows apicomplexan parasites access to a rich source of nutrients in a niche that is largely protected from host defenses. All Apicomplexa adopt a common mode of host-cell entry, but individual species incorporate unique features and utilize a specific set of ligand-receptor interactions. These adhesins ultimately connect to a parasite actin-based motor, which provides the power for invasion. While some Apicomplexa can invade many different host cells, the disease-associated blood-stage form of the malaria parasite is restricted to erythrocytes.|Animals[MESH]|Erythrocytes/*parasitology[MESH]|Forecasting[MESH]|Host-Parasite Interactions[MESH]|Humans[MESH]|Malaria/blood/*parasitology[MESH]|Models, Biological[MESH]|Molecular Motor Proteins[MESH]|Plasmodium falciparum/*physiology/ultrastructure[MESH]|Protozoan Proteins/metabolism[MESH] |