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Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects Manov I; Motanis H; Frumin I; Iancu TCActa Pharmacol Sin 2006[Mar]; 27 (3): 259-72With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.|*Analgesics, Non-Narcotic/adverse effects/toxicity[MESH]|*Anti-Inflammatory Agents, Non-Steroidal/adverse effects/toxicity[MESH]|ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors[MESH]|Acetaminophen/adverse effects/toxicity[MESH]|Acetylcysteine/adverse effects/toxicity[MESH]|Animals[MESH]|Antioxidants/adverse effects/toxicity[MESH]|Aspirin/adverse effects/toxicity[MESH]|Cell Line, Tumor[MESH]|Chemical and Drug Induced Liver Injury[MESH]|Drug Overdose[MESH]|Hepatocytes/*ultrastructure[MESH]|Humans[MESH]|Liver Diseases/*pathology[MESH]|Liver Neoplasms/pathology/ultrastructure[MESH]|Liver/pathology/*ultrastructure[MESH]|Verapamil/adverse effects/toxicity[MESH] |
