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NF-kappaB and IKK as therapeutic targets in cancer Kim HJ; Hawke N; Baldwin ASCell Death Differ 2006[May]; 13 (5): 738-47The transcription factor NF-kappaB and associated regulatory factors (including IkappaB kinase subunits and the IkappaB family member Bcl-3) are strongly implicated in a variety of hematologic and solid tumor malignancies. A role for NF-kappaB in cancer cells appears to involve regulation of cell proliferation, control of apoptosis, promotion of angiogenesis, and stimulation of invasion/metastasis. Consistent with a role for NF-kappaB in oncogenesis are observations that inhibition of NF-kappaB alone or in combination with cancer therapies leads to tumor cell death or growth inhibition. However, other experimental data indicate that NF-kappaB can play a tumor suppressor role in certain settings and that it can be important in promoting an apoptotic signal downstream of certain cancer therapy regimens. In order to appropriately move NF-kappaB inhibitors in the clinic, thorough approaches must be initiated to determine the molecular mechanisms that dictate the complexity of oncologic and therapeutic outcomes that are controlled by NF-kappaB.|*Models, Biological[MESH]|Apoptosis[MESH]|Cell Proliferation[MESH]|Disease Progression[MESH]|Humans[MESH]|I-kappa B Kinase/metabolism/*physiology[MESH]|Inflammation/metabolism[MESH]|NF-kappa B/antagonists & inhibitors/*metabolism[MESH]|Neoplasm Metastasis/pathology[MESH]|Neoplasms/*etiology/immunology/metabolism/*therapy[MESH]|Sensitivity and Specificity[MESH]|Signal Transduction[MESH] |
