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Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice Pasparakis M; Luedde T; Schmidt-Supprian MCell Death Differ 2006[May]; 13 (5): 861-72Studies in transgenic and knockout mice have made a major contribution to our current understanding of the physiological functions of the NF-kappaB signalling cascade. The generation and analysis of mice with targeted modifications of individual components of the NF-kappaB pathway tremendously advanced our knowledge of the roles of the NF-kappaB proteins themselves, and also of the many activators and negative regulators of NF-kappaB. These studies have highlighted the complexity of the NF-kappaB system, by revealing the multiple interactions, redundancies, but also diverse functions, performed by the different molecules participating in the regulation of NF-kappaB signalling. Furthermore, inhibition or enforced activation of NF-kappaB in transgenic mice has uncovered the critical roles that NF-kappaB plays in the pathogenesis of various diseases such as liver failure, diabetes and cancer.|*Transcriptional Activation[MESH]|Animals[MESH]|Genome[MESH]|Liver Diseases/metabolism[MESH]|Liver/metabolism[MESH]|Mice[MESH]|Mice, Knockout/*metabolism[MESH]|Mice, Transgenic/*metabolism[MESH]|Models, Biological[MESH]|NF-kappa B/*metabolism[MESH]|Signal Transduction[MESH]|T-Lymphocytes/metabolism[MESH] |
