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lüll Regulation of ornithine decarboxylase Pegg AEJ Biol Chem 2006[May]; 281 (21): 14529-32Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. The amount of ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to changes in polyamine levels. Susceptibility to tumor development is increased in transgenic mice expressing high levels of ODC and is decreased in mice with reduced ODC due to loss of one ODC allele or elevated expression of antizyme, a protein that stimulates ODC degradation. This review describes key factors that contribute to the regulation of ODC levels, which can occur at the levels of transcription, translation, and protein turnover.|*Gene Expression Regulation, Enzymologic[MESH]|*Promoter Regions, Genetic[MESH]|Alleles[MESH]|Animals[MESH]|Humans[MESH]|Mice[MESH]|Models, Biological[MESH]|Ornithine Decarboxylase/*genetics/*metabolism[MESH]|Polyamines/metabolism[MESH]|Protein Biosynthesis[MESH]|RNA, Messenger/metabolism[MESH]|Transcription, Genetic[MESH] |