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lüll Mitosin/CENP-F in mitosis, transcriptional control, and differentiation Ma L; Zhao X; Zhu XJ Biomed Sci 2006[Mar]; 13 (2): 205-13Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.|*Cell Differentiation[MESH]|*Mitosis[MESH]|*Transcription, Genetic[MESH]|Chromosomal Proteins, Non-Histone/*physiology[MESH]|Humans[MESH]|Microfilament Proteins[MESH]|Muscle Cells/cytology[MESH] |