Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation Chen RH; Wang WJ; Kuo JCJ Biomed Sci 2006[Mar]; 13 (2): 193-9Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integrin inside-out signaling. Using this understanding of DAP-kinase protein function as a framework, we discuss the functional mechanisms of this kinase in regulating death-associated morphological and signaling events. Furthermore, a potential role of DAP-kinase to be a drug target is also discussed.|*Cell Physiological Phenomena[MESH]|Animals[MESH]|Apoptosis Regulatory Proteins[MESH]|Calcium-Calmodulin-Dependent Protein Kinases/*physiology[MESH]|Cell Adhesion[MESH]|Cell Death[MESH]|Cytoskeleton/metabolism[MESH]|Death-Associated Protein Kinases[MESH]|Humans[MESH]|Tumor Suppressor Proteins/physiology[MESH] |