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lüll Mcl-1: a highly regulated cell death and survival controller Yang-Yen HFJ Biomed Sci 2006[Mar]; 13 (2): 201-4Mcl-1 is one member of the Bcl-2 family that has a very short protein half-life. Since its identification in 1993, a great number of studies have implicated that Mcl-1 plays an important role in various cell survival pathways. However, not until recently did the molecular mechanism by which Mcl-1 antagonizes apoptosis have begun to be elucidated. Mcl-1 is rapidly degraded in response to cell death signals and is immediately re-induced by survival stimuli. These results indicate that Mcl-1 plays an apical role in many cell death and survival regulatory programs.|Apoptosis Regulatory Proteins[MESH]|Cell Death[MESH]|Cell Survival[MESH]|Humans[MESH]|Myeloid Cell Leukemia Sequence 1 Protein[MESH]|Neoplasm Proteins/metabolism/*physiology[MESH]|Proto-Oncogene Proteins c-bcl-2/metabolism/*physiology[MESH]|Signal Transduction[MESH] |