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lüll Store-operated Ca2+ channel in renal microcirculation and glomeruli Ma R; Du J; Sours S; Ding MExp Biol Med (Maywood) 2006[Feb]; 231 (2): 145-53Store-operated Ca2+ channel (SOC) is defined as a channel that opens in response to depletion of the internal Ca2+ stores. During the last decade, many investigators have made a great effort to identify and characterize SOC, and to evaluate its physiologic function and pathophysiologic relevance in a variety of cell lines, primary cultures, and native tissues. To date, accumulating evidence has demonstrated that SOC is an essential Ca2+ entry mechanism in vascular smooth-muscle cells of renal microvasculature and glomerular mesangial cells, both of which tightly control glomerular hemodynamics and filtration. Store-operated Ca2+, combined with other types of Ca2+ entry channels, constitutes a profile of Ca2+ changes in response to physiologic vasoconstrictors and, thereby, regulates renal microcirculation and mesangial function. In addition, SOC is associated with altered Ca2+ signaling occurring in diseased kidneys, such as diabetic nephropathy. Although the gating mechanism and molecular identity of SOC are still enigmatic and may be cell-type and tissue specific, data from several independent groups suggest that protein kinase C plays an important role in SOC activation and that certain isoforms of canonical transient receptor potential (TRPC) proteins are candidates of SOC in renal microvessels and mesangial cells.|*Microcirculation[MESH]|*Renal Circulation[MESH]|Calcium Channels/*metabolism[MESH]|Calcium Signaling/physiology[MESH]|Calcium/metabolism[MESH]|Cells, Cultured[MESH]|Humans[MESH]|Kidney Glomerulus/cytology/*metabolism[MESH]|Kidney/*blood supply[MESH]|TRPC Cation Channels/metabolism[MESH] |