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Methylglyoxal comes of AGE Ramasamy R; Yan SF; Schmidt AMCell 2006[Jan]; 124 (2): 258-60The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.|Aging/metabolism[MESH]|Animals[MESH]|Gene Expression Regulation/drug effects/*physiology[MESH]|Genome/drug effects[MESH]|Glycation End Products, Advanced/*biosynthesis[MESH]|Glycosylation[MESH]|Humans[MESH]|Proteome/drug effects[MESH]|Pyruvaldehyde/*metabolism/pharmacology[MESH] |
