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lüll An overview of hereditary hearing loss Bayazit YA; Yilmaz MORL J Otorhinolaryngol Relat Spec 2006[]; 68 (2): 57-63Understanding the genetic basis of hearing loss is important because almost 50% of profound hearing loss are caused by genetic factors and more than 120 independent genes have been identified. In this review, after a brief explanation of some genetic terms (allele, heterozygosis, homozygosis, polymorphism, genotype and phenotype), classification of genetic hearing loss (syndromic versus nonsyndromic, and recessive dominant, X-linked and mitochondrial) was performed. Some of the most common syndromes (Usher, Pendred, Jervell and Lange-Nielsen, Waardenburg, branchio-oto-renal, Stickler, Treacher Collins and Alport syndromes, biotinidase deficiency and Norrie disease) causing genetic hearing loss were also explained briefly. The genes involved in hearing loss and genetic heterogeneity were presented.|Alleles[MESH]|DNA, Mitochondrial/genetics[MESH]|Genetic Heterogeneity[MESH]|Genotype[MESH]|Hearing Loss/classification/*genetics[MESH]|Humans[MESH]|Inheritance Patterns[MESH]|Phenotype[MESH]|Polymorphism, Genetic[MESH]|Syndrome[MESH] |