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Septal networks: relevance to theta rhythm, epilepsy and Alzheimer s disease Colom LVJ Neurochem 2006[Feb]; 96 (3): 609-23Information processing and storing by brain networks requires a highly coordinated operation of multiple neuronal groups. The function of septal neurons is to modulate the activity of archicortical (e.g. hippocampal) and neocortical circuits. This modulation is necessary for the development and normal occurrence of rhythmical cortical activities that control the processing of sensory information and memory functions. Damage or degeneration of septal neurons results in abnormal information processing in cortical circuits and consequent brain dysfunction. Septal neurons not only provide the optimal levels of excitatory background to cortical structures, but they may also inhibit the occurrence of abnormal excitability states.|*Theta Rhythm[MESH]|Alzheimer Disease/*physiopathology[MESH]|Animals[MESH]|Epilepsy/*physiopathology[MESH]|Humans[MESH]|Nerve Net/*physiopathology[MESH]|Neurons/metabolism/*physiology[MESH]|Septum of Brain/*physiopathology[MESH] |
