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Caveolins in vascular smooth muscle: form organizing function Hardin CD; Vallejo JCardiovasc Res 2006[Mar]; 69 (4): 808-15Caveolae are becoming increasingly recognized as an important organizational structure for a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions of smooth muscle: contraction, growth/proliferation, and the energetic support systems that support these functions. With clear alterations in cell metabolism and function in VSM with altered caveolin-1 (Cav-1) protein expression and with cardiovascular abnormalities associated with Cav-1 null mice, the caveolin family of proteins may play an important role in the function and dysfunction of VSM.|Animals[MESH]|Atherosclerosis/metabolism[MESH]|Caveolins/*metabolism[MESH]|Cell Differentiation/physiology[MESH]|Cell Proliferation[MESH]|Humans[MESH]|Muscle Contraction/*physiology[MESH]|Muscle, Smooth, Vascular/*physiology[MESH]|Signal Transduction/*physiology[MESH] |
