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International Union of Pharmacology XLVII Nomenclature and structure-function relationships of voltage-gated sodium channels Catterall WA; Goldin AL; Waxman SGPharmacol Rev 2005[Dec]; 57 (4): 397-409The family of voltage-gated sodium channels initiates action potentials in all types of excitable cells. Nine members of the voltage-gated sodium channel family have been characterized in mammals, and a 10th member has been recognized as a related protein. These distinct sodium channels have similar structural and functional properties, but they initiate action potentials in different cell types and have distinct regulatory and pharmacological properties. This article presents the molecular relationships and physiological roles of these sodium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties.|Animals[MESH]|Electrophysiology[MESH]|Humans[MESH]|Ion Channel Gating/*physiology[MESH]|Sodium Channel Blockers/pharmacology[MESH]|Sodium Channels/classification/drug effects/genetics/*physiology[MESH]|Structure-Activity Relationship[MESH]|Terminology as Topic[MESH] |
