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  • Role of astrocytes in glutamate homeostasis: implications for excitotoxicity
  • Schousboe A; Waagepetersen HS
  • Neurotox Res 2005[Nov]; 8 (3-4): 221-5
  • Glutamate homeostasis in the brain is maintained by its well balanced release, uptake and metabolism. It appears that astrocytes play a prominent role in this context since they possess a very powerful battery of glutamate transporters. Thus, malfunction of astrocytic glutamate transporters will lead to an excessively high extracellular glutamate concentration which may result in neurodegeneration caused by the excitotoxic action of glutamate.
  • |Animals[MESH]
  • |Astrocytes/*drug effects/metabolism[MESH]
  • |Glutamic Acid/*metabolism/*toxicity[MESH]
  • |Homeostasis/drug effects/*physiology[MESH]
  • |Models, Biological[MESH]





  • *{{pmid16371316}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=16371316 Role of astrocytes in glutamate homeostasis: implications for excitotoxicity ]</b> Neurotox Res 2005; 8(3-4) ; 221-5 Schousboe A; Waagepetersen HS

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    Neurotox Res

    221 3-4.8 2005