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lüll Maintenance treatment of bipolar disorders Rybakowski JNeuro Endocrinol Lett 2005[Aug]; 26 Suppl 1 (ä): 49-65Conventional antipsychotic drugs, although efficacious in the treatment of mania, have not demonstrated a significant usefulness in the maintenance treatment of bipolar disorder. This has primarily been due to a tendency to induce depressive symptoms and depressive recurrences in this group of patients in the course of long-term administration. However, the picture has changed following the introduction of second-generation antipsychotics. These drugs have pro-depressant properties (if any) that are much weaker than conventional antipsychotics. Furthermore, their tolerability, especially in long-term treatment, is more favorable compared to classical antipsychotics. Clinical observations of the action profile of second-generation antipsychotic drugs in the treatment of schizophrenia have pointed to a possibility of these agents possessing mood-stabilizing properties. The first such suggestion was made by Zarate (1995) in connection with clozapine. The prevention of manic and depressive recurrences in bipolar disorder is a hallmark of the definition of mood-stabilizers.|Antidepressive Agents, Second-Generation/*administration & dosage[MESH]|Antipsychotic Agents/*administration & dosage[MESH]|Bipolar Disorder/*drug therapy[MESH]|Clinical Trials as Topic[MESH]|Humans[MESH]|Treatment Outcome[MESH] |