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Artificial ribonucleases Niittymaki T; Lonnberg HOrg Biomol Chem 2006[Jan]; 4 (1): 15-25Mimicking the action of enzymes by simpler and more robust man-made catalysts has long inspired bioorganic chemists. During the past decade, mimics for RNA-cleaving enzymes, ribonucleases, or, more precisely, mimics of ribozymes that cleave RNA in sequence-selective rather than base-selective manner, have received special attention. These artificial ribonucleases are typically oligonucleotides (or their structural analogs) that bear a catalytically active conjugate group and catalyze sequence-selective hydrolysis of RNA phosphodiester bonds.|Catalysis[MESH]|Metals[MESH]|Molecular Mimicry[MESH]|Oligonucleotides/chemical synthesis[MESH]|Protein Engineering/*methods[MESH]|Ribonucleases/*chemical synthesis[MESH]|Substrate Specificity[MESH] |
