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Genomics in C elegans: so many genes, such a little worm Hillier LW; Coulson A; Murray JI; Bao Z; Sulston JE; Waterston RHGenome Res 2005[Dec]; 15 (12): 1651-60The Caenorhabditis elegans genome sequence is now complete, fully contiguous telomere to telomere and totaling 100,291,840 bp. The sequence has catalyzed the collection of systematic data sets and analyses, including a curated set of 19,735 protein-coding genes--with >90% directly supported by experimental evidence--and >1300 noncoding RNA genes. High-throughput efforts are under way to complete the gene sets, along with studies to characterize gene expression, function, and regulation on a genome-wide scale. The success of the worm project has had a profound effect on genome sequencing and on genomics more broadly. We now have a solid platform on which to build toward the lofty goal of a true molecular understanding of worm biology with all its implications including those for human health.|*Genome, Helminth[MESH]|Animals[MESH]|Caenorhabditis elegans/*genetics[MESH]|DNA, Helminth/chemistry/genetics[MESH]|Evolution, Molecular[MESH]|Gene Expression Regulation[MESH]|Genomics/*methods/trends[MESH]|Proteomics/methods/trends[MESH]|Sequence Analysis, DNA[MESH] |
