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lüll Surgery versus medical follow-up in patients with asymptomatic primary hyperparathyroidism: a decision analysis Sejean K; Calmus S; Durand-Zaleski I; Bonnichon P; Thomopoulos P; Cormier C; Legmann P; Richard B; Bertagna XY; Vidal-Trecan GMEur J Endocrinol 2005[Dec]; 153 (6): 915-27OBJECTIVES: To examine the cost-effectiveness of strategies for management of primary asymptomatic hyperparathyroidism: surgical strategies and medical follow-up versus surgery. DESIGN: We used a Markov state-transition decision-analytic model for an hypothetical cohort of 55-year-old women to compare with a lifetime horizon costs and effectiveness of bilateral neck exploration (BNE), unilateral neck exploration (UNE), video-assisted parathyroidectomy (VAP) and lifelong medical follow-up shifting for either BNE or UNE in case of disease progression. METHODS: Data on localization tests, complications and treatment efficacies were derived from a systematic review of the literature. Outcomes were expressed as quality-adjusted life years (QALY). Costs (2002 Euro) discounted at 3% yearly were estimated from the health care system perspective. RESULTS: In the base-case analysis, VAP strategy (VAPS) was the most effective and BNE strategy (BNES) was the least costly. UNE strategy (UNES) had an incremental cost-effectiveness ratio of 2688 Euro/QALY versus BNES and VAPS of 17,250 Euro/QALY in comparison with UNES. Surgical management was more effective than medical follow-up with acceptable incremental cost-effectiveness ratios. VAPS became less effective than UNES over 71 years. Differences between UNES and VAPS were sensitive to success and complication rates, quality-of-life weights and procedural costs. Medical follow-up strategies became the most effective if quality-of-life weight for this condition was higher than 0.99. CONCLUSIONS: Surgery is more effective than medical follow-up at a reasonable cost and can be preferred except in patients choosing medical follow-up. Minimally invasive surgery is cost-effective compared to the traditional surgical approach.|*Decision Support Techniques[MESH]|Cost-Benefit Analysis[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Humans[MESH]|Hyperparathyroidism, Primary/*surgery/*therapy[MESH]|Middle Aged[MESH]|Parathyroidectomy[MESH]|Quality of Life[MESH] |