Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Molecular and cellular mechanisms of pharmacoresistance in epilepsy Remy S; Beck HBrain 2006[Jan]; 129 (Pt 1): 18-35Epilepsy is a common and devastating neurological disorder. In many patients with epilepsy, seizures are well-controlled with currently available anti-epileptic drugs (AEDs), but a substantial (approximately 30%) proportion of patients continue to have seizures despite carefully optimized drug treatment. Two concepts have been put forward to explain the development of pharmacoresistance. The transporter hypothesis contends that the expression or function of multidrug transporters in the brain is augmented, leading to impaired access of AEDs to CNS targets. The target hypothesis holds that epilepsy-related changes in the properties of the drug targets themselves may result in reduced drug sensitivity. Recent studies have started to dissect the molecular underpinnings of both transporter- and target-mediated mechanisms of pharmacoresistance in human and experimental epilepsy. An emerging understanding of these underlying molecular and cellular mechanisms is likely to provide important impetus for the development of new pharmacological treatment strategies.|Animals[MESH]|Anticonvulsants/pharmacology/*therapeutic use[MESH]|Biological Transport[MESH]|Blood-Brain Barrier[MESH]|Brain/metabolism[MESH]|Drug Resistance/*genetics/physiology[MESH]|Epilepsy/drug therapy/*metabolism[MESH]|Forecasting[MESH]|Glutamic Acid/metabolism[MESH]|Humans[MESH]|Ion Channels/genetics[MESH]|Models, Animal[MESH]|Multidrug Resistance-Associated Proteins/genetics/metabolism[MESH]|gamma-Aminobutyric Acid/metabolism[MESH] |
