Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease Fadeel B; Orrenius SJ Intern Med 2005[Dec]; 258 (6): 479-517Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the maintenance of tissue homeostasis in the adult organism. Numerous studies in recent years have revealed that apoptosis is a constitutive suicide programme expressed in most, if not all cells, and can be triggered by a variety of extrinsic and intrinsic signals. Many human diseases can be attributed directly or indirectly to a derangement of apoptosis, resulting in either cell accumulation, in which cell eradication or cell turnover is impaired, or cell loss, in which the apoptotic programme is inadvertently triggered. In addition, defective macrophage engulfment and degradation of cell corpses may also contribute to a dysregulation of tissue homeostasis. An increased understanding of the signalling pathways that govern the execution of apoptosis and the subsequent clearance of dying cells may thus yield novel targets for therapeutic intervention in a wide range of human maladies.|*Disease[MESH]|Adult[MESH]|Animals[MESH]|Apoptosis/*physiology[MESH]|Autoimmune Diseases/physiopathology[MESH]|Caspase Inhibitors[MESH]|Caspases/metabolism[MESH]|Cell Survival/physiology[MESH]|Heart Diseases/physiopathology[MESH]|Homeostasis/physiology[MESH]|Humans[MESH]|Inflammation/physiopathology[MESH]|Mitochondria/physiology[MESH]|Neoplasms/physiopathology[MESH]|Neurodegenerative Diseases/physiopathology[MESH]|Signal Transduction/physiology[MESH] |