Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Red cell enzymes Prchal JT; Gregg XTHematology Am Soc Hematol Educ Program 2005[]; ä (ä): 19-23Mutations leading to red cell enzyme deficiencies can be associated with diverse phenotypes that range from hemolytic anemia, methemoglobinemia, polycythemia, and neurological and developmental abnormalities. While most of these mutations occur sporadically, some such as common glucose-6-phosphate dehydrogenase (G6PD) mutants are endemic and rarely cause disease. Common G6PD mutants likely reached their prevalence because they provide some protection against severe malarial complications. In this review G6PD, pyruvate kinase, 5' nucleotidase, and cytochrome b5 reductase deficiencies will be discussed in greater detail. Limitations of commonly used screening tests for detection of these disorders will also be emphasized, as well as emerging knowledge about non-enzymatic function of the glycolytic enzymes.|5'-Nucleotidase/blood/deficiency/genetics[MESH]|Anemia, Hemolytic/blood/*enzymology/genetics[MESH]|Cytochrome-B(5) Reductase/blood/deficiency/genetics[MESH]|Erythrocytes/*enzymology[MESH]|Genetic Variation[MESH]|Glucosephosphate Dehydrogenase Deficiency/blood/complications/*genetics[MESH]|Glucosephosphate Dehydrogenase/blood/genetics[MESH]|Glycolysis[MESH]|Humans[MESH]|Malaria/complications[MESH]|Methemoglobin/genetics[MESH]|Methemoglobinemia/blood/*enzymology/genetics[MESH]|Polycythemia/blood/*enzymology/genetics[MESH]|Pyruvate Kinase/blood/deficiency/genetics[MESH] |
