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lüll Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P Wu LJ; Xu H; Ko SW; Yoshimura M; Zhuo MMol Pain 2005[Nov]; 1 (ä): 34Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function through a direct excitation of GABAergic interneurons by substance P released from primary afferent fibers and has a distinct temporal phase of action from the well-described glutamate-dependent feed-forward inhibition. It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord.|Afferent Pathways/metabolism[MESH]|Animals[MESH]|Humans[MESH]|Neural Inhibition/*physiology[MESH]|Nociceptors/metabolism[MESH]|Pain/*metabolism[MESH]|Posterior Horn Cells/*metabolism[MESH]|Presynaptic Terminals/*metabolism[MESH]|Receptors, Neurokinin-1/metabolism[MESH]|Spinal Nerve Roots[MESH]|Substance P/*metabolism[MESH]|Synaptic Transmission/*physiology[MESH] |