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lüll The development of mouse APECED models provides new insight into the role of AIRE in immune regulation Pereira LE; Bostik P; Ansari AAClin Dev Immunol 2005[Sep]; 12 (3): 211-6Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy is a rare recessive autoimmune disorder caused by a defect in a single gene called AIRE (autoimmune regulator). Characteristics of this disease include a variable combination of autoimmune endocrine tissue destruction, mucocutaneous candidiasis and ectodermal dystrophies. The development of Aire-knockout mice has provided an invaluable model for the study of this disease. The aim of this review is to briefly highlight the strides made in APECED research using these transgenic murine models, with a focus on known roles of Aire in autoimmunity. The findings thus far are compelling and prompt additional areas of study which are discussed.|AIRE Protein[MESH]|Animals[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Mice, Transgenic[MESH]|Mutation[MESH]|Polyendocrinopathies, Autoimmune/*etiology/genetics/immunology[MESH]|Transcription Factors/chemistry/deficiency/genetics/*immunology[MESH] |