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Acid acclimation by Helicobacter pylori Sachs G; Weeks DL; Wen Y; Marcus EA; Scott DR; Melchers KPhysiology (Bethesda) 2005[Dec]; 20 (ä): 429-38Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to approximately 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.|*Adaptation, Physiological[MESH]|Animals[MESH]|Gastric Acid/*metabolism[MESH]|Helicobacter pylori/metabolism/*physiology[MESH]|Humans[MESH]|Urease/metabolism[MESH] |
