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The many roads to cross-presentation Groothuis TA; Neefjes JJ Exp Med 2005[Nov]; 202 (10): 1313-8Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system, in which the machinery required for peptide loading of MHC class I molecules is introduced directly into the phagosome. Here, we discuss the evidence for and against the ER-phagosome concept as well as other possible mechanisms of cross-presentation.|Animals[MESH]|Cross-Priming/*immunology[MESH]|Endoplasmic Reticulum/immunology[MESH]|Humans[MESH]|Phagosomes/immunology[MESH]|T-Lymphocytes, Cytotoxic/immunology[MESH] |
