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Claudin proteins in human cancer: promising new targets for diagnosis and therapy Morin PJCancer Res 2005[Nov]; 65 (21): 9603-6The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. Although the exact roles of these proteins in tumorigenesis are still being uncovered, it is clear that they represent promising targets for cancer detection, diagnosis, and therapy.|Claudin-3[MESH]|Claudin-4[MESH]|Humans[MESH]|Membrane Proteins/*biosynthesis/chemistry/metabolism[MESH]|Neoplasms/diagnosis/*metabolism/therapy[MESH]|Tight Junctions/metabolism[MESH] |
