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lüll Rodent model systems for studies of HIV-1 associated dementia Persidsky Y; Potula R; Haorah JNeurotox Res 2005[Oct]; 8 (1-2): 91-106Understanding of HIV-1 neuropathogenesis and development of rationale therapeutic approaches requires relevant animal models. The putative mechanisms of neuroinflammatory and neurotoxic events triggered by HIV-1 brain infection are reflected by a number of rodent models. These include transgenic animals (either expressing viral proteins or pro-inflammatory factors), infection with murine retroviruses, and severe combined immunodeficient (SCID) mice reconstituted with human lymphocytes and injected intracerebrally with HIV-1-infected human monocyte-derived macrophages. The potential importance and limitations of the models in reflecting human disease are discussed with emphasis on their utility for development of therapies to combat HIV-1-associated neurologic impairment.|AIDS Dementia Complex/*pathology/*psychology[MESH]|Animals[MESH]|Disease Models, Animal[MESH]|Encephalitis, Viral/pathology/psychology[MESH]|HIV-1[MESH]|Humans[MESH]|Mice[MESH]|Mice, SCID[MESH]|Mice, Transgenic[MESH]|Rats[MESH]|Retroviridae[MESH] |