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The neuronal death protein par-4 mediates dopaminergic synaptic plasticity Mattson MP; Gleichmann MMol Interv 2005[Oct]; 5 (5): 278-81Par-4, discovered in a screen for genes whose expression is increased in prostate tumor cells undergoing apoptosis, participates in physiological and pathological nerve cell death. A new study, however, provides evidence for an unexpected role for Par-4 in regulating synaptic transmission in the brain: Par-4 binds to the D2 dopamine receptor (D2DR) and modulates its activity. Mice in which the function of Par-4 is disrupted exhibit impaired dopaminergic neurotransmission, resulting in a depression-like syndrome. Several other cell death-related proteins also appear to function in regulating synaptic plasticity, suggesting that a better understanding of the functions of these proteins may lead to novel therapeutic approaches for a psychiatric and neurodegenerative disorders.|*Dopamine[MESH]|*Neuronal Plasticity[MESH]|Animals[MESH]|Apoptosis Regulatory Proteins/metabolism/*physiology[MESH]|Humans[MESH]|Receptors, Dopamine D2/agonists[MESH]|Synapses/*physiology[MESH]|Synaptic Transmission[MESH] |
