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lüll The role of apoptosis in the development and function of T lymphocytes Zhang N; Hartig H; Dzhagalov I; Draper D; He YWCell Res 2005[Oct]; 15 (10): 749-69Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work together to regulate T lymphocyte development and function.|*Apoptosis[MESH]|Animals[MESH]|Mice[MESH]|Proto-Oncogene Proteins c-bcl-2/metabolism[MESH]|Receptors, Tumor Necrosis Factor/metabolism[MESH]|Signal Transduction[MESH]|T-Lymphocytes/cytology/*immunology[MESH]|Thymus Gland/cytology/growth & development/immunology[MESH] |