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lüll The devil in the details: the emerging role of anticitrulline autoimmunity in rheumatoid arthritis van Gaalen F; Ioan-Facsinay A; Huizinga TW; Toes REJ Immunol 2005[Nov]; 175 (9): 5575-80Rheumatoid arthritis is a chronic inflammatory autoimmune disease of unknown cause. The immune response against citrullinated Ags has recently become the prime suspect for disease pathogenesis. Immunity against citrullinated Ags is thought to play a pivotal role in the disease for several reasons: 1) citrullinated Ags are expressed in the target organ, the inflamed joint; 2) anti-citrullinated protein Abs are present before the disease becomes manifest; and 3) these Abs are highly specific for rheumatoid arthritis. In this review, data from clinical, genetic, biochemical, and animal studies is combined to create a profile of this remarkable autoantibody response. Moreover, a model is proposed of how the anti-citrullinated proteins response is generated and how it could eventually lead to chronic inflammation.|*Autoimmunity[MESH]|Antigen-Antibody Complex/physiology[MESH]|Arthritis, Rheumatoid/*etiology/immunology[MESH]|Autoantibodies/immunology[MESH]|Citrulline/*immunology[MESH]|Humans[MESH]|Hydrolases/physiology[MESH]|Protein-Arginine Deiminases[MESH] |